Some users had some issues with the PortX360 crashing, not letting them use the PortX360.
With the help of Rob (I will not write his full name) that reported this issue to me, I was able to find a solution.

The XNA framework version (3.1) link I attached with the PortX360 is NOT the correct framework to use with the PortX360.

To fix this issue you must install Microsoft XNA Framework 3.0 from this link:
http://www.microsoft.com/downloads/details.aspx?familyid=6521d889-5414-49b8-ab32-e3fff05a4c50&displaylang=en



This should fix the crashing and let you use the PortX360.